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CORE DIRECTOR, ANTIBODY ENGINEERING

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Posting Details

Posting Details

Reference Number 40-27024
Posted Job Title CORE DIRECTOR, ANTIBODY ENGINEERING
School Name Perelman School of Medicine
Org DM-Gene Therapy Program
Posted to the Web 10/11/2017
Posted Job/Salary Grade 030
Employment Type Exempt
Hours N/A
Position Type Full Time
Position Schedule 8-5
Months 12
Position Length Contingent Upon Funding
Position End Date
University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

School/Center Overview

The Perelman School of Medicine at the University of Pennsylvania is the oldest and one of the finest medical schools in the United States. Penn is rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since its founding in 1765 the School has been a strong presence in the community and prides itself on educating the leaders of tomorrow in patient care, biomedical research, and medical education. http://www.med.upenn.edu/

Duties

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the ‘go-to’ organization for public and private partners, who want to participate in the gene therapy space.

We are currently looking for a Core Director, Antibody Engineering to provide investigators and their teams with access to sophisticated antibody/protein engineering support services to facilitate groundbreaking gene therapy research. A successful candidate will have a thorough knowledge of principles of antibody engineering and have hands-on experience in antibody molecular biology. S/he also will be leading the antibody engineering, humanization, and affinity maturation projects; working closely with experienced scientists in the characterization of the antibody candidates in a dynamic, fast-paced and highly collaborative environment.

As the Core Director, you will be the primary technical resource for antibody engineering and research for all of GTP at PENN. You will be responsible for overall core operations, management, financial, safety, and compliance matters about the core. You may supervise and direct the activities of research specialists reporting to you. Also, in collaboration with the PI of the Gene Therapy Program and Directors of Research, you will contribute to assessing the rare disease programs of GTP to determine the antibody engineering needs.

Joining GTP offers scientific professionals the unique opportunity of seeing research go from bench to bedside and discoveries that could one day lead to cures.

Responsibilities:
* Antibody and multi-specific antibody engineering
* Direct experience with humanization and affinity maturation strategies and conduction
* Determination of kinetic constants, and epitope mapping
* Serve as a technical lead on projects in a cross-functional team setting and act as a champion for the antibody development
* Take an active role in coaching and mentoring other scientists in the lab.

Qualifications
  • A Master’s Degree in immunology, molecular biology, oncology, pharmacology or related life sciences and 5 years to 7 years of experience in antibody engineering, or an equivalent combination of education and experience, are required. Ph.D. strongly preferred.
    * Experience working with antibody/fusion protein large molecules drug development
    * Expertise designing, cloning, and transfection of expression constructs, expression, purification and characterization of binders
    * Expertise in determination of kinetic constants, epitope binning and mapping
    * Expertise in humanization, affinity maturation, and reformatting of antibodies
    * Proven track record of scientific accomplishments demonstrated by publications in high-impact journals, or successful experiences in Bio-pharm industry
    * Strong interpersonal and management skills
    * Good skills in written and oral communication, organization and multitasking, and working in a highly collaborative and cross-functional research environment
    * Excellent team player and leadership skills, highly reliable and responsible.
Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements
Quick Link http://jobs.hr.upenn.edu/postings/31968

Posting Supplemental Questions

Required fields are indicated with an asterisk (*).

  1. * How did you hear about this employment opportunity?
    • Jobs@Penn
    • Contacted by a Penn Recruiter
    • Referred by a Penn Employee
    • Referred by a friend or family member
    • Higher Education Recruitment Consortium (HERC)
    • Inside Higher Ed
    • Indeed.com
    • Other Internet Advertisement
    • Linkedin
    • Twitter
    • Other Social Media Site
    • Professional Affiliation/Trade Website
    • Diversity Association/Publication Website
    • Heard about it at a conference or career fair
    • Apple One
    • Recruitment and/or staffing agency
  2. * What is your highest level of education completed?
    • Less than high school education
    • High School Diploma or GED
    • Vocational or Technical School
    • Associate's Degree or Two Year College
    • Bachelor's Degree
    • Master's Degree
    • PHD/MD/JD or equivalent doctoral degree
  3. * How many years of experience do you have related to this position?
    • 0 to 1 Year
    • 1 to 2 Years
    • 2 to 3 Years
    • 3 to 5 Years
    • 5 to 7 Years
    • 7 to 10 Years
    • Over 10 Years

Applicant Documents

Required Documents
  1. Resume
Optional Documents
  1. Cover Letter